Child Labor In Business Essay Example | Topics and Well Written Essays - 2000 words

Child Labor In Business - Essay Example These are consistency and universalisability as well as human dignity. The maxim of consistency and universalisability requires individuals within business enterprises to act in correspondence with the maxim while the maxim of human dignity requires fair treatment of humanity â€Å"as an end instead of a means to an end† (Makkreel and Luft 47). This conjecture offers a basis for the progress of extensive and honorable rules that can effectively guide the operations of a business enterprise in terms of ethical considerations. For example, it can guide an organisation to make laws and codes of conduct based on the 1998 ILO Declaration on Fundamental Principles and Rights at Work. This declaration calls for the effective closing down of institutions abusing child labor. The philosophical interpretations of this theory are applicable when addressing the malpractice of child labor in business because it is majorly concerned with goodwill as the rational motivation for human beings. In essence, business managers who subscribe to this theory will understand that children are rational human beings who should be motivated by the good will of education, care, play and treatment instead of exposure to inhuman treatment of child labor. Besides, the theory highlights the need for respect, human rights and equality for all. This is in contrast to the ideals of child labor where children are exposed to harsh treatment. Extensively overworking anybody including a child has adverse and detrimental effects on the health, psychological, physical and welfare of the child (Makkreel and Luft 47). Child labor within businesses is enormous and complex. Kantianism faces several shortcomings as it tries to address these shortcomings. This is because the theory assumes that humans are... This essay stresses that child labor within businesses is enormous and complex. Kantianism faces several shortcomings as it tries to address these shortcomings. This is because the theory assumes that humans are independent rational beings. However, this is false children because the factors that drive children into child labor are beyond their control. Children lack the capacity to make appropriate decisions, and lack independence to support their choices. This report makes a conclusion that business managers can eliminate child labour by focusing on the act of utilitarianism and the rule of utilitarianism. In the act of utilitarianism, it is necessary to review the consequences of individual actions and calculate its usefulness during performance. The rule of justice operates â€Å"under the veil of ignorance† and demands that each individual should enjoy equal rights. The resultant liberties should match the related liberty systems for other people. In this regard, the social and economic inequalities need correction to address the needs of the disadvantaged and provide equal and fair opportunities to everyone. This is especially the case in positions or offices where people seek services. Based on this understanding, the social contract theory is applicable in business organisations that lack existing regulations that encourage the growth of child labour. The application of social contract theory will ensure that business org anisations consider the rights and justices.

Hispanic American Diversity Essay Example | Topics and Well Written Essays - 1250 words - 4

Hispanic American Diversity - Essay Example Hispanics share the heritage of the Spanish language but many do not speak Spanish at all. Among the Mexican Americans, 23 percent speak English, 26 percent are bilingual and 51 percent are Spanish dominant. The society is concerned about their immigrant status and is often confused whether their stay is legal or illegal. The Mexican Americans comprise of the affluent as well as poor peasants. They usually come from low income background and have less formal education. They have made gain in formal schooling but still lag behind most Hispanics. Family and religion are a great source of strength to the community. They have religious preference for the Catholic Church. The court of law does not provide protection for the poor, Spanish-speaking. The community has a culture of poverty as they have no future planning, no commitment to marriage and no work ethic. They prefer to adhere to their Mexican culture. As the number of Mexican Americans is growing, they have become conscious voters . Thus subgroup is politically conscious and when they did not get any response from the established politicians, they set up their own party. The Mexican Americans are eligible for dual nationality. Even if their children are born in America, they can claim Mexican nationality, although dual nationality does not give them voting rights in Mexico. They can be found in large number in New York. Puerto Ricans are English-oriented with about 39 percent being English-dominant and 40 percent of the population being bi-lingual. Only 21 percent of the Puerto Ricans are Spanish-dominant. This subgroup too, is challenged by the immigrant officials but they have the same voting rights as other Americans. Puerto Ricans are no longer concentrated in New York but are dispersed throughout New Jersey, Illinois, Florida and California. They are more familiar with the US culture and the English language. Unemployment among the mainland Puerto Ricans is high. They have a vibrant

International economics - Balance of Payments Coursework

International economics - Balance of Payments - Coursework Example The transactions of imports and exports done by United Kingdom can be in terms goods, services, financial transfers and financial capital. According to park if the sovereign payments are greater than autonomous receipts, the balance of payment will at disequilibrium. A country like United Kingdom which is experiencing balance of payment deficits in its current will be required to make up an increasing financial debt so that it posses more foreign assets (Park 2004, p. 122). Basically there are three types of balance of payments deficits. They include visible trade deficit, basic deficit and current account deficit. There are four in which United Kingdom measures its current account deficit. They include the net current income for example income from overseas investment, the balance of trade in goods, transfer of payments for example payments made to European Union and lastly the balance of trade in goods. The other factors that causes imbalance in balance if payment apart from the fall of value in pound include, A decrease in the current account is caused by a period of consumption led economic increase or growth. If consumption and consumer spending is increased within the United Kingdom, it will lead automatically to an increased expenditure on imports (Park 2004, p. 31). Given in 2011 and 2010, the domestic economy was experiencing massive growth with an increased consumer spending and inflation. This caused to a large gap of deficit on the current account. Recently recession has led to a temporary improvement in the deficit after most consumer cut back on their spending. A nation with individuals and firms saving lowly with a high percentage of consumption will automatically also have a higher current account deficit hence causing disequilibrium of balance of payment. The relative competitiveness of industrial production of

Coursework on Budgets Example | Topics and Well Written Essays - 2000 words

On Budgets - Coursework Example Budgets are prepared in definite procedural definitions. They can be prepared for the business as a whole; they may fall under designated departments. Budgets can also be prepared for functions of the organization such as sales, production or even for the asset utilization of the organization (Hammonds, 2006). A budget can as well be prepared for the resources of the company such as financial resources and even other resource items of the organization such as cash, capital expenses, relevant purchases of the firm and not excluding labor. Work force is the most vital for any firm to run since it is that which supports production and without production there can be nothing much to brag about involvement in business (Label, 2010). Why budget? A budget is not just a tool that can be used for any mere business operations. They are not mere calculations that are simply drawn, calculated and findings just presented. They are elaborate plans hence involves a construction of a plan that is ge ared for use for a quite a longer duration and hence a tool for financial management (Gowthorpe, 2005). A business that operates without a budget is as good as dead since it is likely to experience management difficulties in the organization. Therefore, the main objective of a budget is to help in aiding an organization set objectives or targets to be achieved in specific period in time or time span. After targets are set, they are the guidelines of the business operations. They are the driving force for the business. This is as a result that the business will make all the necessary efforts to ensure that they either fully o r partly achieve these targets (Donovan, 2005). A case in study is where a firm decides that it intends to sell 100000 units of a product in a certain definite financial period for example a year, the firm will obviously make all the necessary arrangements to ensure that the firm will achieve the set target. The arrangements may entail even putting forth a elabo rate and efficient production plan which will ensure constant supply for the sales target. It is true the management will make all the necessary efforts to ensure this objective is arrived at. If the budget is achieved or partly satisfied i.e. about 80% and above. It means that only about 80000 units of sale are made creating room for the analysis of the variation. Then it gives the management a chance to investigate the reasons that this has occurred. In the event that the reasons are identified viable ways of overcoming the causes is exploited to make sure that the problem is eradicated or reduced. This alone is a minimization of the risk of loss of any business. The preparation of a budget is therefore important in the maximization of the profits of the business (Label, 2010). Budgeting principles A proactive and effective budget normally has four basic principles that guide their establishment. These principles entail the following:- One must be conservative in making a budget. Assuming that you were to make budgets far much outside what does not take place. The budget may not be operational on such grounds. Therefore a budget should not be prepared and expecting that the outcome be the same as budgeted. There always has to be a deviation from the normal due to the difference in environments of operation including time line. Another principle is

Dealing with Stress and Violence in the Workplace Essay

Dealing with Stress and Violence in the Workplace - Essay Example ed of systems of interventions that are supposed to prevent the negative psychological reactions that arise from dealing with many critical incidents in the line of duty. The management tool is designed to address critical incident stress at an early stage to prevent post traumatic stress becoming permanent in exposed individuals. The tool facilitates the normal recovery of individuals, groups and organizations back to normalcy after a traumatic experience. The management tool also assists in the identification of personnel within an organization who need further attention in emotional support services or psychological treatment in severe cases (Human Resources Branch, 1997) A CISM program uses multidimensional approach to prevent post traumatic stress on personnel exposed to traumatic situations, the tool promotes pre-event stress and crisis management education, training and preparation for management of traumatic stress and incorporates planning and policy development to that effect. The programs have various interventions that are used when a traumatic event is happening, and interventions after the traumatic events have occurred. Many approaches and interventions are integrated together to form a systematic interlinked approach to management of stress (Mitchell, n.d). Stress management tools are expected to help individuals, emergency personnel groups and communities deal with the impact of critical incidents and enable them to live with some degree of normalcy after these events. Stress management tools reduce incidences of chronic stress in personnel, which has negative effects on an individual’s life. Yes; I believe that the stress management tool is useful in dealing with violence in the workplace because all employees are able to share their experiences which help in reducing psychological stress and promote faster healing. When used effectively, the CIS management tools allow early detection of employees suffering from post-traumatic stresses that

English Poem Analysis Essay Example for Free

English Poem Analysis Essay In this poem, Pablo Neruda is talking about life, and how he feels that it is an insignificant business. He talks about life after death, saying that nobody keeps what they have and says that life is nothing but a borrowing of bones. The best thing he claims to have learnt from life is that one should not have too much of either joy or sadness, but experience both in equal quantities. He feels that his being happy was a punishment, a condemnation that caused him to plunge into the sorrows of others, and to share with them their sorrow. He says that he did not do this for fame or for money, but because he could not live in the shadows, the shadows of other people. He says that we can heal our own wounds by weeping and singing, but in front of us lie thousands of others who are in constant suffering. He feels that his business on earth was to fulfil his spirit, the happiness he felt with the sum of all his actions. It gave him great joy to bathe in the sea under the sun, and in the very foam of the sea, his heart which lay dying was seeped into the sand. The poet makes use of immense imagery in all his works. There is no poem written by Pablo Neruda, which is lacking imagery. It is one of the most common literary devices used by the poet. And this is one such poem where he has used various kinds of imagery to illustrate his thoughts.

Impact of Cyanobacteria Toxins

Impact of Cyanobacteria Toxins Introduction Cyanobacteria, or also known as blue-green algae is one of the bacteria phylum. It was classified as blue-green algae because it resembles eukaryotic green algae. Cyanobacteria are photosynthetic prokaryotes which have the ability to synthesize chlorophyll a. Chlorophyll a primarily absorbs most red and blue light, which allow cyanobacteria to obtain energy. This energy was then used to synthesize carbohydrate from carbon dioxide and water. Water is used as electron donor during the photosynthesis process and produces oxygen as a byproduct. Thus, the ability of cyanobacteria underwent the process of photosynthesis leading to the evolution of oxygen as they play an important role in increasing the amount of oxygen in Earth. Besides, cyanobacteria also called blue-green algae because of its ability to form the phycobilin pigment (phycocyanin). Phycocyanin is an accessory pigment where it works in conjunction with chlorophyll a. Phycocyanin pigment is the one that give bluish colour to cyanobacteria. According to Dittmann and Wiegand (2006), the lyses of a cyanobacterial bloom leads to release of high amounts of blue pigmented. However, the colour can degrade under condition of high exposure to light and heat (Jespersen et al., 2005). Because cyanobacteria are prokaryote, it is usually small and unicellular. Usually individual cyanobacteria are round, oval, globular or string-like in shape. However, cyanobacteria often growth in colonies and, thus are large and easily to view. These colonies are built of many layers and can form filaments, sheets or even hallow ball depend on its species and environmental condition. Cyanobacteria have been classified into five groups based on their morphologies. There are chrooccales (I), pleurocapsales (II), oscillatoriales (III), nostacales (IV) and stigonematales (V). Group l is unicellular cyanobacteria that divide by binary fusion or budding, while group II is unicellular form that divide by multiple fission. Then, group III is filamentous colonies that reproduce by trichome breakage (Henson, 2002). However, only groups IV and V are supported by phylogenetic studies and make up the heterocystous cyanobacteria. They have the ability to fix Nitrogen such as genera of Anabaena, Nostoc, and etc. Cyanobacteria are extremely successful organism that can adapt in any condition depend on its species. The fossil record shows their existence since 3.5 billion years ago and it are still around. According to Hitzfeld et al. (2000), the cyanobacteria inhabitants vary from hot springs to temporary frozen ponds in Antarctica. Cyanobacteria are gram negative that has cell wall made up of peptidoglycan and lipopolysaccharide layers that surrounded by gelatinous and mucilaginous sheath. The presence of the gelatinous sheath may help in survival of cyanobacteria during extreme conditions and desiccation (Duy et al., 2000). Cyanobacteria mostly found in brackish, freshwater, rivers, lakes, ponds and some reservoirs. They commonly live in such condition to get access of water and sunlight, as they do the photosynthesis process. The high accumulation of cyanobacteria is due to nutrient enrichment (eutrophication). The eutrophication is the process of water bodies gets the excess of nutrient a nd this promotes extremely growth of cyanobacteria. This nutrient may come from many sources, such as fertilizers applied to agriculture, erosion of soil containing nutrients and etc. The excess of nutrient lead to massive population of cyanobacteria, include the blooms, scums, and mats and biofilms (Codd et al., 2005). The existence of cyanobacteria bloom can reduce dissolved oxygen in water and may cause other aquatic organisms died. Alperdoorn et al. (2007) suggest that complex interaction of high concentration of nutrients, sunlight, warm temperature, turbidity, pH, conductivity, salinity, carbon availability and slow-flowing stagnant water are involved in production of blooms. Besides, the bloom of cyanobacteria is related with toxins released. Purpose of study The purpose of study is to analyze the type of toxins produced by bloom of cyanobacterial. Growth of cyanobacteria bloom is favored by nutrient enrichment. The increase of mass population of cyanobacteria will lead to high amount of toxin produced. Then, relate how these toxins act in order to affect humans and animals health. Objectives of study Production and mode of action of cyanobacteria Occurrence of cyanobacterial toxins in affects humans and animals -example case Routes of exposure Diseases in Humans and Animals Conclusion further work Production and mode of action of cyanobacteria toxins Properties of cyanobacterial toxins There are around 150 genera with about 2000 species of cyanobacteria has been recognized, as according to the current taxonomy. However, out of them, only 40 genera have been identified to produce toxins (Hitzfeld et al., 2000). The toxins produced by bloom of cyanobacteria are sometimes called cyanotoxins. The genera that release toxins from cyanobacteria bloom are include Microcystis, Anabaena, Anabaenopsis, Plankthothrix, Aphanizomenon, Cylindrospermopsis, Raphidiopsis and Nodularia (Codd et al., 2005). Cyanotoxins are classified into two grouped, where one is based on their modes of toxin affect the animals cells or cell system, and the other one is based on their chemical composition and structure (Codd et al.,1999). The first grouped are divided into four types, which are hepatotoxins, neurotoxins, cytotoxin and irritant toxins (Codd et al., 2005). However, the second grouped is classify into three different chemical structure which are cyclic peptides, alkaloids and lipopolysa ccharides (LPS) (Sivonen Jones 1999). The production of cyanotoxin are highly variable depends on time and an individual bloom itself. Besides, the arrangement of the genes and their expression under certain environmental condition also contribute in released the toxins. Hepatotoxins-cyclic peptides Hepatotoxins class has the chemical structure of cyclic peptides. These kinds of toxins are released by bloom of cyanobacteria that ranging from freshwater to oceans. Among the common hepatotoxins produced are mycrocystins and nodularins. Microcystin is first found in the early 1980 and isolated from Microcystis aeruginosa. Thus, the toxins were named as microcystin (Sivonen Jones 1999). Then, it was identified that microcystins also have been produced from the genera of Anabaena, Microcystis, Planktothrix, Nostoc and Anabaenopsis (Hitzfeld et al., 2000). Differ from microcystins, where nodularins only produced by the genera of Nodularia and were names as nodularins after its producer, Nodularia spumigena (Falconer 1998). Both are widespread cyanotoxins because the presence of gas vesicle that provides buoyancy. Gas vesicles enable them to float up or sink in order to get sunlight and reach the site of nutrient-rich layers (Dittmann Wiegand 2006). Enough of nutrient and sunlight en able the cyanobacteria to undergo the photosynthesis process and lead to excess growth. Therefore, the cyanotoxins of microcystins and nodularins could be produce enormously and can disturb the ecosystems Microcystins are difference from nodularins based on their chemical structure of cyclic peptides. The chemical structures of microcystins have been identified as cyclic heptapeptides, while nodularins has chemical structure of cyclic pentapeptides (Codd et al., 1999). Cyclic heptapeptides refer to microcystins that contain seven peptide-linked amino acids. There are five common amino acids and another two L-amino acids are varied (Park et al., 1993). The five common amino acids are D-erythro-ÃŽ ²-methylaspartic acid, D-alanine, N-methyldehydroalanine, D-glutamate and Adda-3-amino-9-methoxy-2, 6, 8-trimethyl- 10-phenyldeca-4, 6-dienoic acid. The variable L amino acids are located at position 2 and 4. The variable of L amino acids increased the variations in microcsytins structure and so far there are about 70 structural variables have been identified (Codd et al., 2005). Besides that, demethylation of D-erythro-ÃŽ ²-methylaspartic acid and N-methyldehydroalanine amino acids also give variation in microcystin structure. In contrast, only about 6 variant of nodularins structure have been recognized (Codd et al. 1999). Both microcystins and nodularins only release from cyanobacteria bloom once it was lyses. These toxins are potent inhibitors of eukaryotic protein phosphotases activity (Park et al., 1993). According to Codd et al, (2005), this inhibition can change the membrane integrity and causing tumor production and liver damage. Liver is the main targeting organ in this action of toxins. Neurotoxin-alkaloids Neurotoxins contain the chemical structure of alkaloids. Alkaloids are chemical compound that contains any basic nitrogen atoms and produced by cyanobacteria. It cause toxic that act on nerve cell (neuron). So far, three known families of neurotoxins are anatoxin-a, anatoxin-a(S) and saxitoxins. Anatoxin-a acts by mimic acetylcholine, while anatoxin-a(S) inhibit acetylcholinesterase. Next, saxitoxins which relatively associated with paralytic shellfish poisons (PSP) are works by block the sodium channels. These toxins have been reported found mostly in area of North America, Europe and Australia (Sivonen Jones 1999). Devlin et al. (1977), identified anatoxins-a as a secondary amine 2-acetyl-9-azabicyclo (4-2-1)non-2-ene. Anatoxin-a is usually released by Anabaena flos-aquae, Anabaena spp, Anabaena planktonica, Oscillatoria, Aphanizomenon and Cylindrospermum (Sivonen and Jones, 1999). This toxins cause symptoms such as fasciculation, gasping and convulsion, when infection occurred in animals (Mazur et al., 2003). In contrast, Anatoxin-a(S) is guanidine methyl phosphate ester and produced by Anabaena flos-aquae and Anabaena lemmermannii (Codd et al., 2005). However, its structure still h as not been recognized. Sanitoxins are group of carbonate alkaloids and about 20 of structural variations has been recognized (Codd et al., 2005). Sanitoxins are produced by species of Anabaena, Aphanizomenon, Cylindrospermopsis, Lyngbya, Planktothrix and Trichodesmium (Carmichael et al., 2001) Cytotoxin-alkaloids Cylindrospermopsin is the example of cytotoxin released and has been found in tropical and subtropical water such as in lakes, rivers and water supply reservoir (Falconer 1998). According to Hitzfeld et al (2000) and Codd et al (1999), cylindrospermopsin could also be categorized as hepatotoxins because it affects liver damage. However, Codd et al (2005) and Falconer (1998) have categorized it under cytotoxin class because its action as an inhibitor of protein synthesis. This inhibition cause damage to tissue that rapidly synthesize protein such as pituitary gland, epithelia including gut lining, the pancreas, lymphoid tissue and the prostate gland, as well as the kidneys and liver (Falconer 1998). This toxin is also genotoxic, which can cause loss of chromosome and break of DNA strand (Humpage et al 2000). Cylindrospermopsin is a cyclic guanidine alkaloid and has been isolated mainly from cylindrospermopsis raciborskii and also from Aphanizomenon ovalisporum, Umezakia natans, Aphani zomenon flosaquae and Raphidiopsis curvata (Falconer and Humpage, 2006). Irritant toxins Irritant toxins are usually related with skin irritant (dermatoxin). Aplysiatoxin and lyngbyatoxin is alkaloid structure and both are the most toxins that cause skin irritation. Aplysiatoxin is produced by genera of Lyngbya, Oscillatoria and Schizothrix whereas Lyngbyatoxin is produced by Lyngbya (Codd et al 1999). Aplysiatoxin also is potent tumour promoters and Lyngbyatoxin also caused severe oral and gastrointestinal inflammation (Sivonen and Jones, 1999). LPS endotoxin released by cyanobacteria is less potent than released by bacteria, such as Salmonella (Codd et al 1999). LPS is localized at outer membrane wall of cyanobacteria and contain lipid A that responsible for much of toxicity of cyanobacteria. LPS endotoxin in cyanobacteria is produced by Microcystis, Oscillatoria and Anabaena (Codd et al 1999). The signs and symptoms of this toxin are fever, rigors, headache, nausea, mild amnesia and diarrhea (Stewart et al., 2006). According to Codd et al (2005), it may contribute to inflammatory and gastrointestinal incidents. Toxin Chemical structure Producer Genera Primary target organ Hepatotoxins Microcystins Cyclic heptapeptides Microcystis, Anabaena, Planktothrix, Nostoc Anabaenopsis Liver Nodularins Cyclic pentaptides Nodularia Liver Neurotoxins Anatoxin-a Alkaloids Anabaena, Oscillatoria and Aphanizomenon, Cylindrospermum Microcystis Nerve synapse Anatoxin-a(s) Alkaloids Anabaena Nerve synapse Saxitoxins Alkaloids Aphanizomenon, Anabaena, Lyngbya Cylindrospermopsis Nerve axon Cytotoxins Cylindrospermosin Cyclic guanidine alkaloids Cylindrospermopsis, Aphanizomenon, Umezakia Rhapidiopsis Tissue damage include liver and kidney Irritant toxins Lyngbyatoxin Alkaloids Lyngbya Skin, GI tract Aplysiatoxin Alkaloids Lyngbya, Oscillatoria Schizothrix Skin Endotoxins LPS Microcystis, Oscillatoria Anabaena Potential irritant affect any exposed tissues Table 1: Updated from Codd et al. (1999) and Sivonen Jones (1999). This shows the summaries of general features of cyanotoxins. Occurrence of cyanobacterial toxins The cases of cyanotoxins affect humans and animals have been reported occurred throughout the world. This include part of Europe (such as Belgium, France, Germany, UK, etc), America (at least 27 states), Middle East and Asia (such as Bangladesh, Saudi Arabia, Thailand), Australasia (such as Australia, New Zealand), Africa (Botswana, Morocco) and also Marine Atlantic Ocean (Baltic Sea, Caribbean sea) and Antarctica (McMurdo Ice Shelf) (Codd et al., 2005). From the case reported, cyanatoxins affect animals, include wild and domestic mammals, birds, amphibians and fish, while human cases ranging from acute to chronic (Hitzfeld et al., 2000). The first case of cyanotoxins occurred in animals was the death of cattle, sheep, dogs, horses and pigs. This took placed in Lake Alexandrina, Australia in 1878. The death of these animals was due to drink the water that contains a scum of Nodularia spumigena (Francis, 1878) . After this case, numerous cases have been reported and most commonly involved death of farm animals after drinking the contaminated water with cyanobacterial bloom (Hitzfeld et al., 2000). For example, in 1991 the death of sheep has been recorded in Darling River, Australia. This death occurred after drinking from a farm dam contaminated with saxitoxins, released by Anabaena circinalis (Goodman et al., 1999). Besides, the cases of dog deaths after swimming in, or eating, cyanobacteria also occurred. In 1992, death of dogs at Loch Insh, Scotland happened after swimming was due to release of Anatoxin-a by Oscillatoria sp. into the water (Edwards et al., 1992). Among the earliest reported cases involving acute effect in humans was a series of town along the Ohio River, US in 1931. It start when the water of a side branch of the river develop a cyanobacteria bloom because of low rainfall. This water was then washed into the main river and caused a series of gastroenteritis once it moves downstream (Tisdale 1931). However, the toxins caused this outbreak is unknown and the organism that released this toxins was unspecified. Then, another case involving the same diseased, (gastroenteritis) was reported in Harare, Zimbabwe in 1966. This time Microcystis aeruginosa was the one that has been identified responsible in this case, but the toxins released was still not known (Hitzfeld et al., 2000). Children living in this area developed gastroenteritis each year as they use the water reservoir which contains a natural bloom of Microcystis (Zilberg 1966). The case of chronic effects in humans may be present due to short exposure to toxins (Goodman et al., 1999). The incidence in China, 1995 due to microcystins have lead to chronic of liver injury, hepatocellular carcinoma. This is primary cancer of the liver and most are secondary to hepatitis B infection. From the case analyzed, cyanobacteria are abundant in surface waters of south east China, where the incidence of hepatocellular carcinoma is highest. Thus, it has been concluded that microcystins in the drinking water are responsible for the increased of liver cancer (Falconer 1998). Compare to all cyanotoxins, cyclic peptides (mostly microcystins) has high risk because of their potential to develop diseases in long term time, even when exposed to low concentration of cyanotoxins. This was confirmed after examined all the cases reported, where the major injury is hepatotoxicosis, cause liver damage. In contrast, neurotoxin mostly shows acute effect in mammals (Goddman et al., 1999). Routes of exposure There are many ways where humans and animals can be exposed to cyanotoxins. From the cases reported, animals usually infected by cyanotoxins orally via drinking contaminated water. For instance, the case reported of cattle deaths in Alpine Lakes, Switzerland (1974-1994). The cattle died because of liver damage after drinking the water which contains bloom of cyanobacteria (Hitzfeld et al., 2000). Besides, human can get infection of cyanotoxins during the recreational activity involving direct contact with water such as swimming, canoeing and paddling (Apeldoorn et al., 2007). In 1989, UK, some of army recruits showed symptoms of infected by cyanotoxins after swimming and canoes training in water with dense bloom of Mocrocystis. The signs of symptoms were vomiting, diarrhea, blistering of the lips, sore throat and central abdominal pain (Turner et al., 1990). The person that worked in the area of water such as boatmen and environmental scientists are also easily to get infection. Acco rding to Dittmann and Wiegand (2006), the consumption of blue green algae containing food and dietary supplements, such as pills or capsules, also can lead to gain the toxicity of cyanobacteria. According to Codd et al (1999), there are four routes of exposure where human can get infection of cyanotoxins (Table 2). The first one is via oral routes, taken by ingestion during recreational activity, drinking water, food and dietary supplements that contain dried cyanotoxins. The oral route has caused the outbreak of many diseased, such as gastroenteritis and hepatoenteritis after drinking water (Codd et al 1999). Infection by pulmonary route occurs either by inhalation of cyanobacteria bloom during recreational activity or work practices in industrial spray water (Codd et al., 1999). Next, dermal route is associated with skin or mucosal contact the contaminated water. This can lead to skin irritation and allergic reaction. Lastly, haemodialysis route can occurred via water used in haemodialysis treatment. Among the cases of this route, is the case of major fatal incident at haemodialysis clinic in Caruaru, Brazil. This case happened in 1996, where the patients with dialysis tre atment were treated with water from local reservoir. All patients experienced symptoms of nausea, vomiting, muscle weakness and painful hepatomegaly. Then, these patients developed acute liver failure and acute neurotoxicity signs. From all the treated patients, 60 have been recorded as dead. Microcystins released by Aphanizomenon and Oscillatoria have been recognized as the toxins that responsible for this death (Codd et al., 1999). Exposure route Exposure medium Oral (ingestion) drinking water, recreational water, food (shellfish, finfish if toxin if toxin accumulation has occurred during production), dietary supplements (pills, capsules) if contains dried cyanobacterial cells with toxins. Pulmonary (inhalation, aspiration) water: aerosols, spray during recreation, work, showering Dermal water during recreation, work, showering (skin, mucosal contact) Haemodialysis water used for haemodialysis Table 2: Taken from Codd et al., 2005. This figure summaries the human exposure route and exposure medium for cyanotoxins. Diseases in Animals and Humans Hepatoenteritis Liver damage Hepatoenteritis is described as hepatitis-like illness, where associated with liver problem. This diseased can infect both human and animals. The outbreak of hepatoenteritis disease was reported in 1979 and occurred in Palm Island of the Queensland, Australia. Thus, this case also name as â€Å"Palm Island Mystery Disease† because the water drinking is supply from Palm Island reservoir (Ohtani et al., 1992). Investigation have shown that the reservoir contain the bloom of Cylindrospermopsis raciborskii. This species released cylindrospermopsin and responsible for developed of severe hepatoenteritis among the 140 children and 10 adults. The common symptoms of this disease are malaise, anorexia, vomiting, painful liver enlargement, dehydration and bloody diarrhea. This toxin is very water soluble and infect into body by oral route via drinking water. According to Falconer and Humpage (2006), the mechanism of action for cylindrospermopsin is relatively slow. It work by inhibit pr otein synthesis at ribosome during the peptide chain elongation step. Besides, the toxins also released CYP450 oxidation that work to inhibit the glutathione synthesis. Both inhibitions caused major changes in liver, particularly hepatocytes. First, accumulation of ribosomes in the cytoplasm of hepatocytes and followed by membrane proliferation. Next, the accumulation of lipid in the central portion of hepatic lobules and all this lead to severe liver necrosis (Duy et al., 2000). Kidney, lung, heart, spleen and thymus also might be affects. The toxins of microcystins are majorly involved in liver damage. Most of microcystins types are hydrophilic and thus, not able to penetrate vertebrate cell membrane. It only can uptake into cell membrane via transporter. Once the microcystins are uptake by mammals, it is transport into the blood from the ileum via bile acid type transporter, that present in hepatocytes (Apeldoorn et al 2007). As a result, the present of microcystins is higher in liver due to active uptake by hepatocytes. Once inside the hepatocytes, microcystins act as potent inhibitor of eukaryotic protein phosphatases 1 and 2A. These inhibitions cause changes in cytoskeletal proteins, and thus results in deformation of hepatocytes. The liver may undergo changes in term of a disruption of hepatocytes structure due to damage of cytoskeleton, loss of sinusoidal structure, increased in liver weight because of intrahepatic haemorrhage, heart failure and death. Gastroenteritis Gastroenteritis is inflammation of the gastrointestinal tract, where involved stomach and intestine. This diseased can be cause by infection from cyanobacteria bloom of Microcystis sp and Anabaena sp. Acording to Hitzfeld et al (2000), the cases of gastroenteritis that have been recorded due to cyanobacteria bloom were occured in Ohio River, US (1931), Harare, Zimbabwe (1966) and Itaparica Dam, Brazil (1993). However, the toxins that responsible for this diseased still remain unknown because lack of available toxin analysis method and knowledge of candidate toxins at the time (Codd et al., 1999). Recently, there is case where LPS endotoxin is responsible for gastroenteritis incidents (Codd et al., 2005). Gastroenteritis is categorized under acute effect and mostly results in diarrhea. Besides, the symptoms shows are nausea and vomiting, loss of appetite, fever, headaches and abnormal pain. Respiratory problem Neurotoxins effects can lead to progressive paralysis and death because of respiratory failure. The case of livestock death in Europe and the US have been reported due to anatoxin-a, released from the genera of Oscillatoria, Aphanizomenon and Anabaena (Falconer, 1998). Anatoxin-a acts as a potent postsynaptic depolarizing neuromuscular blocking agent, where it binds to neuronal nicotinic acetylcholine receptors of neuromuscular junction (Goodman et al., 1999) .This cause postsynaptic sodium channel of neuron is remain open and lead to continuous stimulation of sodium ion influx and continuously generates action potential. Consequently, the muscle contraction is over react and might be followed by fatigue and respiratory failure (Dittmann and Wiegand, 2006). This toxin can cause rapidly death depending on the species and amount of toxin ingested. The clinical sign of this infection are muscle fasciculation, decreased movement, abdominal breathing, cyanosis, and death by respiratory fa ilure. Saxitoxins are another type of neurotoxins that can infect both human and animals. As mention before, the case of Darling River in Australia (1990-1991) involved the deaths of sheep and cattle due to saxitoxins. Then, in human, saxitoxins have been the cause of paralytic shellfish poisoning (PSP). Saxitoxins acts as a blocking agent of sodium channel in nerve axons. In mammals, this induces muscle paralyzed (respiratory muscle) and can follow by death due to respiratory failure (Apeldoorn et al., 2007). Skin irritation and allergic Lyngbya majuscula is one of the cyanobacteria that released aplysiatoxin and lyngbyatoxin. These toxins act as potent skin tumour promoters. Both toxins, especially aplysiatoxin, cause skin irritation after contact with bloom of Lyngbya majuscula. Swimmers of Hawaii and Okinawa got acute dermatitis (causing itch), erythematous wheals and desquamation after contact with Lyngbya majuscule (Codd et al., 1999). Besides, symptoms have included rashes, blisters, allergic reaction, asthma, conjunctivitis, and eye irritation. Conclusion The development of cyanobacterial bloom tends to be favored by nutrient enrichment (eutrophication). Therefore, enough nutrients will provide extremely growth of cyanobacteria bloom and thus, lead to high production of cyanotoxins once it is lyses. The most clearly study of toxins is microcystins due to widespread of its production among the cyanobacteria blooms. Besides, their existences that usually can be found in lakes, rivers and water supply reservoirs also lead to increased the chance to affect humans and animals health compare to the other toxins. As mention above, there are four routes where infection of cyanotoxins could occurs, which are by oral route, dermal route, pulmonary route and lastly via haemodialysis route. Once the toxins get inside humans and animals, they will start reacts and disturb the system inside the body according to its modes of actions. Therefore, it leads to outbreak of many diseased such as hepatoenteritis, gastroenteritis, respiratory problem and s kin irritation and allergic. However, till now there are some mechanism of toxins that still not understood, such as lyngbyatoxins (Goodman et al., 1999).Then, further work also need to be done in order to solve the cases of unknown toxic affect humans and animals that have been recorded. For example, the case of the outbreak of gastroenteritis diseased occurred in Ohio River, US (1931), Harare, Zimbabwe (1966) and Itaparica, Dam, Brazil (1993), where no actual toxins have been identified (Hitzfeld et al., 2000). 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